http://gandg.cloud/api.php?action=feedcontributions&feedformat=atom&user=Mwood 2026-08-17T08:03:35Z User contributions MediaWiki 1.39.1 http://gandg.cloud/index.php?title=Maca&diff=967 2026-07-21T13:36:41Z

<p>Mwood: </p> <hr /> <div>The whole Maca scene is quite complex, so here is some data.<br /> <br /> The colour of the root (it is really just the skin) is determined by the plant itself. You plant Maca seeds and the roots grow and the ratios are usually 60-70% yellow, 20-25% red and 10-15% black. You can read up on it in below link. There is also sometimes a purple root, but technically it is classed as red.<br /> <br /> Several years ago Chinese companies bought up a whole harvest of Maca roots from Peru (illegally) by getting them smuggled across the border into Bolivia and then shipped to China, where they were planted and now they can supply their own Maca. I don’t know many people who knowingly buy Chinese Maca, most want South American, quite rightly. Having said that, we started getting customers wanting cheaper extracts and the R3713 is Chinese origin.<br /> <br /> Most extracts are a blend of mixed coloured roots, if you start to specify the actual colour, then they get more expensive. A 20:1 extract takes 20kgs of roots to make 1kg of extract and if you want black maca, that is only 10-15% of the crop.<br /> <br /> If you don’t mind Chinese material we can get, 5:1, 8:1, 10:1, 35:1 and 100:1 black maca extracts.<br /> If you want Peruvian black maca, we can only get a 10:1 from my current suppliers and it will be more expensive than Chinese material.<br /> <br /> https://themacaexperts.com/maca/learn-about-maca/what-are-the-different-colours-of-maca/<br /> <br /> Also, for a description of gelatinisation of Maca you can read this:<br /> https://www.vivolife.co.uk/blogs/news/a-big-maca-mistake-gelatinised-vs-raw-maca-powder/<br /> <br /> [[Category:Ingredients]]</div>

Mwood http://gandg.cloud/index.php?title=Berberine&diff=966 2026-07-08T11:58:40Z

<p>Mwood: </p> <hr /> <div>Berberine is found in such plants as Berberis vulgaris (barberry), Berberis aristata (Indian barberry or tree turmeric), Mahonia aquifolium (Oregon grape), Hydrastis canadensis ([[goldenseal]]), Xanthorhiza simplicissima (yellowroot), Phellodendron amurense (Amur cork tree), Coptis chinensis (Chinese goldthread), Tinospora cordifolia, Argemone mexicana (prickly poppy), and Eschscholzia californica (Californian poppy). <br /> <br /> As of 27/4/2023 there is a public consultation from EFSA looking at the safety of berberine containing plants, this will be updated when new information is released. <br /> <br /> An email from the HFMA on 27/8/24 stated: <br /> <br /> Berberis aristata and products containing Berberis in general may require final determinations by the MHRA regarding their classification as borderline products. It is our understanding that the MHRA generally regards this herb as medicinal and its classification as a medicine may also depend on the specific part of the plant used, which could have implications for safety concerns. <br /> <br /> Overall, there is strong evidence that herb itself has medicinal uses, therefore one might presume that a substance isolate from this herb would also be considered medicinal.  For a definitive answer, I would recommend that you contact the MHRA Borderline Advice team on borderline_medicine@mhra.gov.uk<br /> <br /> Regarding isolated berberine, as an isolated substance, it is likely to be considered novel when used in foods. Consequently, there is a potential risk in marketing a product containing berberine as a food supplement in the UK. Ultimately, the company would bear the responsibility of defending its use as a food supplement should its suitability be questioned.<br /> <br /> As for the EU, there are varied national restrictions/authorised and unauthorised parts of Berberis aristata, for example:<br /> <br /> * In France, the roots only are authorised in food supplements, under the following conditions:<br /> <br /> Doctrine teledeclaration October 2019, updated October 2023: Anses in its 2019 opinion relating to the use of plants with berberine in food supplements recommends that “pregnant and breastfeeding women, diabetics and people with liver or heart disorders should refrain from consuming food supplements containing berberine, due to the adverse effects that may occur. In the absence of specific data, this recommendation also applies to children and adolescents. A pharmacological dose of 400 mg is retained, therefore maximum 380 mg (5% tolerance). The substance to be monitored is: Berberine (recommended: ≤ 380 mg).<br /> <br /> * In Italy, root and bark of the branches are authorised in food supplements. For botanical claims, the Italian authorities already have national provisions: physiological effects listed in Annex 1 Decree of 10 august 2018 (as amended) usable.<br /> * In Hungary, the whole plant is unauthorised in all foods, including food supplements.<br /> * In Belgium, the roots only are authorised in food supplements, the recommended daily amount should not lead to an intake of isoquinoline alkaloids (expressed as berberine) exceeding 10 mg. The substance to be monitored is: Berberine (≤ 10 mg).<br /> * In Estonia, similarly to the UK, there is a risk of classification as medicine, application to Agency of Medicines possible for a case by case analysis. <br /> <br /> Barberry root powder is R2052 in Access, and may be a possible alternative, as there are no active claims, although it would be up to the customer to decide.<br /> <br /> We do have Berberine in Access but it is only for use outside the UK/EU.<br /> <br /> [[Category:Ingredients]]<br /> [[Category:Novel Food]]<br /> [[Category:Medicinal]]</div>

Mwood http://gandg.cloud/index.php?title=SAMe&diff=965 2026-07-03T13:29:53Z

<p>Mwood: </p> <hr /> <div>SAMe ''&quot;S-adenosyl L-methionine&quot;'' is approved in food supplements in Italy, so with EU equivalence it should be usable up to a maximum permitted dose. Could be [[Medicinal ingredients | medicinal]].<br /> <br /> Be aware that it is chemically unstable and degrades very quickly, so other salt forms were investigated, that have prolonged stability.<br /> <br /> However, the current favourite S-adenosyl-L-methionine disulfate tosylate (AMDT) is a Novel Food (May 2026). There are no approved salt forms currently.<br /> <br /> <br /> [[Category:Ingredients]]<br /> [[Category:Medicinal]]<br /> [[Category:Novel Food]]</div>

Mwood http://gandg.cloud/index.php?title=Testing_Methodologies&diff=964 2026-06-26T13:33:11Z

<p>Mwood: </p> <hr /> <div>All botanical ingredients are analysed in a laboratory, either in-house or by an independent third party, to check that the active ingredients are at the correct levels, per the published specification.<br /> ----<br /> There are various methodologies for analytical testing, as far as we are concerned there are three main ones:<br /> <br /> ==1. Spectroscopy (Light &amp; Radiation Interactivity)==<br /> These methods measure how matter absorbs, emits, or scatters electromagnetic radiation to decode molecular structures.<br /> <br /> *FTIR (Fourier-Transform Infrared): Identifies organic polymers and functional groups by measuring molecular vibrations.<br /> *UV-Vis (Ultraviolet-Visible): Quantifies light absorption to find concentrations of coloured compounds in a solution.<br /> *NMR (Nuclear Magnetic Resonance): Maps the carbon-hydrogen framework of complex organic molecules.<br /> *Raman Spectroscopy: Provides a structural fingerprint through non-destructive laser light scattering.<br /> <br /> ==2. Chromatography (Separation Techniques)==<br /> Chromatography forces a liquid or gas sample through a stationary phase to separate individual components based on their physical properties.<br /> <br /> *HPLC (High-Performance Liquid Chemistry): Separates non-volatile liquids, widely used in pharmaceuticals.<br /> *GC (Gas Chromatography): Separates volatile gas mixtures, critical for environmental testing.<br /> * TLC (Thin-Layer Chromatography): A fast, low-cost screening method used to track chemical reaction progress.<br /> <br /> ==3. Mass Spectrometry (MS)==<br /> MS ionizes chemical species and sorts them based on their mass-to-charge ratio, offering unparalleled sensitivity for unknown identification.<br /> <br /> *GC-MS / LC-MS: Couples separation power with mass identification to isolate and name trace contaminants.<br /> *ICP-MS (Inductively Coupled Plasma): Detects ultra-trace metals down to parts-per-trillion (ppt) levels.<br /> <br /> Mass Spectrometry coupled with Chromatography (LC-MS or GC-MS) is the most accurate method for identifying and quantifying active ingredients in botanical extracts. Plant extracts are highly complex chemical &quot;matrices&quot; containing hundreds of distinct phytochemicals that must be separated before they can be accurately measured.<br /> <br /> <br /> ==Accuracy==<br /> We often see test results from UV and HPLC tests which are widely different. This is because stand-alone UV testing (UV-Vis Spectrophotometry) routinely overestimates active ingredients compared to HPLC because UV testing lacks the ability to separate a sample before measuring it.<br /> When a raw botanical extract is placed in a UV spectrophotometer, the machine reads the total light absorbed at a specific wavelength. It cannot distinguish between your target active ingredient and dozens of other identical-looking plant molecules.<br /> The primary reasons for these drastically different results include:<br /> ==1. Total Absorbance vs. Separated Absorbance==<br /> UV-Vis Testing: The sample is placed directly into a glass cuvette. If you are testing for Saffron at 440 nm, the machine counts everything in that liquid that absorbs light at 440 nm. This includes degraded actives, plant pigments, and irrelevant cellular debris.<br /> HPLC Testing: The sample is forced through a chemical column that slows down different molecules at different rates. Your active ingredient is physically separated into its own pure &quot;peak&quot; before it ever hits a detector. HPLC measures only that isolated compound.<br /> == 2. The Overestimation Effect (False Positives)==<br /> Because UV testing tallies up all background chemical &quot;noise,&quot; UV test results are frequently 20% to 200% higher than HPLC results for the exact same batch. Dishonest ingredient suppliers often prefer UV-Vis testing because it artificially inflates the apparent potency of an extract on a Certificate of Analysis (CoA).<br /> ==3. Shared Chromophores==<br /> Molecules absorb ultraviolet light using chemical structures called chromophores (such as alternating double bonds). In a complex botanical extract, many entirely different plant sugars, tannins, or flavonoids share almost identical chromophores. A standalone UV meter sees them all as the exact same substance</div>

Mwood http://gandg.cloud/index.php?title=Testing_Methodologies&diff=963 2026-06-26T13:32:02Z

<p>Mwood: </p> <hr /> <div>All botanical ingredients are analysed in a laboratory, either in-house or by an independent third party, to check that the active ingredients are at the correct levels, per the published specification.<br /> ----<br /> There are various methodologies for analytical testing, as far as we are concerned there are three main ones:<br /> <br /> ==1. Spectroscopy (Light &amp; Radiation Interactivity)==<br /> These methods measure how matter absorbs, emits, or scatters electromagnetic radiation to decode molecular structures.<br /> <br /> *FTIR (Fourier-Transform Infrared): Identifies organic polymers and functional groups by measuring molecular vibrations.<br /> *UV-Vis (Ultraviolet-Visible): Quantifies light absorption to find concentrations of coloured compounds in a solution.<br /> *NMR (Nuclear Magnetic Resonance): Maps the carbon-hydrogen framework of complex organic molecules.<br /> *Raman Spectroscopy: Provides a structural fingerprint through non-destructive laser light scattering.<br /> <br /> ==2. Chromatography (Separation Techniques)==<br /> Chromatography forces a liquid or gas sample through a stationary phase to separate individual components based on their physical properties.<br /> <br /> *HPLC (High-Performance Liquid Chemistry): Separates non-volatile liquids, widely used in pharmaceuticals.<br /> *GC (Gas Chromatography): Separates volatile gas mixtures, critical for environmental testing.<br /> * TLC (Thin-Layer Chromatography): A fast, low-cost screening method used to track chemical reaction progress.<br /> <br /> ==3. Mass Spectrometry (MS)==<br /> MS ionizes chemical species and sorts them based on their mass-to-charge ratio, offering unparalleled sensitivity for unknown identification.<br /> <br /> *GC-MS / LC-MS: Couples separation power with mass identification to isolate and name trace contaminants.<br /> *ICP-MS (Inductively Coupled Plasma): Detects ultra-trace metals down to parts-per-trillion (ppt) levels.<br /> <br /> Mass Spectrometry coupled with Chromatography (LC-MS or GC-MS) is the most accurate method for identifying and quantifying active ingredients in botanical extracts. Plant extracts are highly complex chemical &quot;matrices&quot; containing hundreds of distinct phytochemicals that must be separated before they can be accurately measured.<br /> <br /> <br /> ==Accuracy==<br /> ----<br /> We often see test results from UV and HPLC tests which are widely different. This is because stand-alone UV testing (UV-Vis Spectrophotometry) routinely overestimates active ingredients compared to HPLC because UV testing lacks the ability to separate a sample before measuring it.<br /> When a raw botanical extract is placed in a UV spectrophotometer, the machine reads the total light absorbed at a specific wavelength. It cannot distinguish between your target active ingredient and dozens of other identical-looking plant molecules.<br /> The primary reasons for these drastically different results include:<br /> ==1. Total Absorbance vs. Separated Absorbance==<br /> UV-Vis Testing: The sample is placed directly into a glass cuvette. If you are testing for Saffron at 440 nm, the machine counts everything in that liquid that absorbs light at 440 nm. This includes degraded actives, plant pigments, and irrelevant cellular debris.<br /> HPLC Testing: The sample is forced through a chemical column that slows down different molecules at different rates. Your active ingredient is physically separated into its own pure &quot;peak&quot; before it ever hits a detector. HPLC measures only that isolated compound.<br /> == 2. The Overestimation Effect (False Positives)==<br /> Because UV testing tallies up all background chemical &quot;noise,&quot; UV test results are frequently 20% to 200% higher than HPLC results for the exact same batch. Dishonest ingredient suppliers often prefer UV-Vis testing because it artificially inflates the apparent potency of an extract on a Certificate of Analysis (CoA).<br /> ==3. Shared Chromophores==<br /> Molecules absorb ultraviolet light using chemical structures called chromophores (such as alternating double bonds). In a complex botanical extract, many entirely different plant sugars, tannins, or flavonoids share almost identical chromophores. A standalone UV meter sees them all as the exact same substance</div>

Mwood http://gandg.cloud/index.php?title=Testing_Methodologies&diff=962 2026-06-26T13:31:39Z

<p>Mwood: </p> <hr /> <div>All botanical ingredients are analysed in a laboratory, either in-house or by an independent third party, to check that the active ingredients are at the correct levels, per the published specification.<br /> ----<br /> There are various methodologies for analytical testing, as far as we are concerned there are three main ones:<br /> <br /> ==1. Spectroscopy (Light &amp; Radiation Interactivity)==<br /> These methods measure how matter absorbs, emits, or scatters electromagnetic radiation to decode molecular structures.<br /> <br /> *FTIR (Fourier-Transform Infrared): Identifies organic polymers and functional groups by measuring molecular vibrations.<br /> *UV-Vis (Ultraviolet-Visible): Quantifies light absorption to find concentrations of coloured compounds in a solution.<br /> *NMR (Nuclear Magnetic Resonance): Maps the carbon-hydrogen framework of complex organic molecules.<br /> *Raman Spectroscopy: Provides a structural fingerprint through non-destructive laser light scattering.<br /> <br /> ==2. Chromatography (Separation Techniques)==<br /> Chromatography forces a liquid or gas sample through a stationary phase to separate individual components based on their physical properties.<br /> <br /> *HPLC (High-Performance Liquid Chemistry): Separates non-volatile liquids, widely used in pharmaceuticals.<br /> *GC (Gas Chromatography): Separates volatile gas mixtures, critical for environmental testing.<br /> * TLC (Thin-Layer Chromatography): A fast, low-cost screening method used to track chemical reaction progress.<br /> <br /> ==3. Mass Spectrometry (MS)==<br /> MS ionizes chemical species and sorts them based on their mass-to-charge ratio, offering unparalleled sensitivity for unknown identification.<br /> <br /> *GC-MS / LC-MS: Couples separation power with mass identification to isolate and name trace contaminants.<br /> *ICP-MS (Inductively Coupled Plasma): Detects ultra-trace metals down to parts-per-trillion (ppt) levels.<br /> <br /> Mass Spectrometry coupled with Chromatography (LC-MS or GC-MS) is the most accurate method for identifying and quantifying active ingredients in botanical extracts. Plant extracts are highly complex chemical &quot;matrices&quot; containing hundreds of distinct phytochemicals that must be separated before they can be accurately measured.<br /> <br /> <br /> Accuracy<br /> ----<br /> We often see test results from UV and HPLC tests which are widely different. This is because stand-alone UV testing (UV-Vis Spectrophotometry) routinely overestimates active ingredients compared to HPLC because UV testing lacks the ability to separate a sample before measuring it.<br /> When a raw botanical extract is placed in a UV spectrophotometer, the machine reads the total light absorbed at a specific wavelength. It cannot distinguish between your target active ingredient and dozens of other identical-looking plant molecules.<br /> The primary reasons for these drastically different results include:<br /> ==1. Total Absorbance vs. Separated Absorbance==<br /> UV-Vis Testing: The sample is placed directly into a glass cuvette. If you are testing for Saffron at 440 nm, the machine counts everything in that liquid that absorbs light at 440 nm. This includes degraded actives, plant pigments, and irrelevant cellular debris.<br /> HPLC Testing: The sample is forced through a chemical column that slows down different molecules at different rates. Your active ingredient is physically separated into its own pure &quot;peak&quot; before it ever hits a detector. HPLC measures only that isolated compound.<br /> == 2. The Overestimation Effect (False Positives)==<br /> Because UV testing tallies up all background chemical &quot;noise,&quot; UV test results are frequently 20% to 200% higher than HPLC results for the exact same batch. Dishonest ingredient suppliers often prefer UV-Vis testing because it artificially inflates the apparent potency of an extract on a Certificate of Analysis (CoA).<br /> ==3. Shared Chromophores==<br /> Molecules absorb ultraviolet light using chemical structures called chromophores (such as alternating double bonds). In a complex botanical extract, many entirely different plant sugars, tannins, or flavonoids share almost identical chromophores. A standalone UV meter sees them all as the exact same substance</div>

Mwood http://gandg.cloud/index.php?title=Testing_Methodologies&diff=961 2026-06-26T13:26:38Z

<p>Mwood: </p> <hr /> <div>All botanical ingredients are analysed in a laboratory, either in-house or by an independent third party, to check that the active ingredients are at the correct levels, per the published specification.<br /> ----<br /> There are various methodologies for analytical testing, as far as we are concerned there are three main ones:<br /> <br /> ==1. Spectroscopy (Light &amp; Radiation Interactivity)==<br /> These methods measure how matter absorbs, emits, or scatters electromagnetic radiation to decode molecular structures.<br /> FTIR (Fourier-Transform Infrared): Identifies organic polymers and functional groups by measuring molecular vibrations.<br /> UV-Vis (Ultraviolet-Visible): Quantifies light absorption to find concentrations of coloured compounds in a solution.<br /> NMR (Nuclear Magnetic Resonance): Maps the carbon-hydrogen framework of complex organic molecules.<br /> Raman Spectroscopy: Provides a structural fingerprint through non-destructive laser light scattering.<br /> <br /> ==2. Chromatography (Separation Techniques)==<br /> Chromatography forces a liquid or gas sample through a stationary phase to separate individual components based on their physical properties.<br /> HPLC (High-Performance Liquid Chemistry): Separates non-volatile liquids, widely used in pharmaceuticals.<br /> GC (Gas Chromatography): Separates volatile gas mixtures, critical for environmental testing.<br /> TLC (Thin-Layer Chromatography): A fast, low-cost screening method used to track chemical reaction progress.<br /> <br /> ==3. Mass Spectrometry (MS)==<br /> MS ionizes chemical species and sorts them based on their mass-to-charge ratio, offering unparalleled sensitivity for unknown identification.<br /> GC-MS / LC-MS: Couples separation power with mass identification to isolate and name trace contaminants.<br /> ICP-MS (Inductively Coupled Plasma): Detects ultra-trace metals down to parts-per-trillion (ppt) levels.<br /> <br /> Mass Spectrometry coupled with Chromatography (LC-MS or GC-MS) is the most accurate method for identifying and quantifying active ingredients in botanical extracts. Plant extracts are highly complex chemical &quot;matrices&quot; containing hundreds of distinct phytochemicals that must be separated before they can be accurately measured.<br /> ----<br /> We often see test results from UV and HPLC tests which are widely different. This is because stand-alone UV testing (UV-Vis Spectrophotometry) routinely overestimates active ingredients compared to HPLC because UV testing lacks the ability to separate a sample before measuring it.<br /> When a raw botanical extract is placed in a UV spectrophotometer, the machine reads the total light absorbed at a specific wavelength. It cannot distinguish between your target active ingredient and dozens of other identical-looking plant molecules.<br /> The primary reasons for these drastically different results include:<br /> ==1. Total Absorbance vs. Separated Absorbance==<br /> UV-Vis Testing: The sample is placed directly into a glass cuvette. If you are testing for Saffron at 440 nm, the machine counts everything in that liquid that absorbs light at 440 nm. This includes degraded actives, plant pigments, and irrelevant cellular debris.<br /> HPLC Testing: The sample is forced through a chemical column that slows down different molecules at different rates. Your active ingredient is physically separated into its own pure &quot;peak&quot; before it ever hits a detector. HPLC measures only that isolated compound.<br /> ==2. The Overestimation Effect (False Positives)==<br /> Because UV testing tallies up all background chemical &quot;noise,&quot; UV test results are frequently 20% to 200% higher than HPLC results for the exact same batch. Dishonest ingredient suppliers often prefer UV-Vis testing because it artificially inflates the apparent potency of an extract on a Certificate of Analysis (CoA).<br /> ==3. Shared Chromophores==<br /> Molecules absorb ultraviolet light using chemical structures called chromophores (such as alternating double bonds). In a complex botanical extract, many entirely different plant sugars, tannins, or flavonoids share almost identical chromophores. A standalone UV meter sees them all as the exact same substance</div>

Mwood http://gandg.cloud/index.php?title=Testing_Methodologies&diff=960 2026-06-26T13:26:26Z

<p>Mwood: </p> <hr /> <div>==Summary<br /> All botanical ingredients are analysed in a laboratory, either in-house or by an independent third party, to check that the active ingredients are at the correct levels, per the published specification.<br /> ----<br /> There are various methodologies for analytical testing, as far as we are concerned there are three main ones:<br /> <br /> ==1. Spectroscopy (Light &amp; Radiation Interactivity)==<br /> These methods measure how matter absorbs, emits, or scatters electromagnetic radiation to decode molecular structures.<br /> FTIR (Fourier-Transform Infrared): Identifies organic polymers and functional groups by measuring molecular vibrations.<br /> UV-Vis (Ultraviolet-Visible): Quantifies light absorption to find concentrations of coloured compounds in a solution.<br /> NMR (Nuclear Magnetic Resonance): Maps the carbon-hydrogen framework of complex organic molecules.<br /> Raman Spectroscopy: Provides a structural fingerprint through non-destructive laser light scattering.<br /> <br /> ==2. Chromatography (Separation Techniques)==<br /> Chromatography forces a liquid or gas sample through a stationary phase to separate individual components based on their physical properties.<br /> HPLC (High-Performance Liquid Chemistry): Separates non-volatile liquids, widely used in pharmaceuticals.<br /> GC (Gas Chromatography): Separates volatile gas mixtures, critical for environmental testing.<br /> TLC (Thin-Layer Chromatography): A fast, low-cost screening method used to track chemical reaction progress.<br /> <br /> ==3. Mass Spectrometry (MS)==<br /> MS ionizes chemical species and sorts them based on their mass-to-charge ratio, offering unparalleled sensitivity for unknown identification.<br /> GC-MS / LC-MS: Couples separation power with mass identification to isolate and name trace contaminants.<br /> ICP-MS (Inductively Coupled Plasma): Detects ultra-trace metals down to parts-per-trillion (ppt) levels.<br /> <br /> Mass Spectrometry coupled with Chromatography (LC-MS or GC-MS) is the most accurate method for identifying and quantifying active ingredients in botanical extracts. Plant extracts are highly complex chemical &quot;matrices&quot; containing hundreds of distinct phytochemicals that must be separated before they can be accurately measured.<br /> ----<br /> We often see test results from UV and HPLC tests which are widely different. This is because stand-alone UV testing (UV-Vis Spectrophotometry) routinely overestimates active ingredients compared to HPLC because UV testing lacks the ability to separate a sample before measuring it.<br /> When a raw botanical extract is placed in a UV spectrophotometer, the machine reads the total light absorbed at a specific wavelength. It cannot distinguish between your target active ingredient and dozens of other identical-looking plant molecules.<br /> The primary reasons for these drastically different results include:<br /> ==1. Total Absorbance vs. Separated Absorbance==<br /> UV-Vis Testing: The sample is placed directly into a glass cuvette. If you are testing for Saffron at 440 nm, the machine counts everything in that liquid that absorbs light at 440 nm. This includes degraded actives, plant pigments, and irrelevant cellular debris.<br /> HPLC Testing: The sample is forced through a chemical column that slows down different molecules at different rates. Your active ingredient is physically separated into its own pure &quot;peak&quot; before it ever hits a detector. HPLC measures only that isolated compound.<br /> ==2. The Overestimation Effect (False Positives)==<br /> Because UV testing tallies up all background chemical &quot;noise,&quot; UV test results are frequently 20% to 200% higher than HPLC results for the exact same batch. Dishonest ingredient suppliers often prefer UV-Vis testing because it artificially inflates the apparent potency of an extract on a Certificate of Analysis (CoA).<br /> ==3. Shared Chromophores==<br /> Molecules absorb ultraviolet light using chemical structures called chromophores (such as alternating double bonds). In a complex botanical extract, many entirely different plant sugars, tannins, or flavonoids share almost identical chromophores. A standalone UV meter sees them all as the exact same substance</div>

Mwood http://gandg.cloud/index.php?title=Testing_Methodologies&diff=959 2026-06-26T13:25:58Z

<p>Mwood: </p> <hr /> <div>==Summary==<br /> All botanical ingredients are analysed in a laboratory, either in-house or by an independent third party, to check that the active ingredients are at the correct levels, per the published specification.<br /> ----<br /> There are various methodologies for analytical testing, as far as we are concerned there are three main ones:<br /> <br /> ==1. Spectroscopy (Light &amp; Radiation Interactivity)==<br /> These methods measure how matter absorbs, emits, or scatters electromagnetic radiation to decode molecular structures.<br /> FTIR (Fourier-Transform Infrared): Identifies organic polymers and functional groups by measuring molecular vibrations.<br /> UV-Vis (Ultraviolet-Visible): Quantifies light absorption to find concentrations of coloured compounds in a solution.<br /> NMR (Nuclear Magnetic Resonance): Maps the carbon-hydrogen framework of complex organic molecules.<br /> Raman Spectroscopy: Provides a structural fingerprint through non-destructive laser light scattering.<br /> <br /> ==2. Chromatography (Separation Techniques)==<br /> Chromatography forces a liquid or gas sample through a stationary phase to separate individual components based on their physical properties.<br /> HPLC (High-Performance Liquid Chemistry): Separates non-volatile liquids, widely used in pharmaceuticals.<br /> GC (Gas Chromatography): Separates volatile gas mixtures, critical for environmental testing.<br /> TLC (Thin-Layer Chromatography): A fast, low-cost screening method used to track chemical reaction progress.<br /> <br /> ==3. Mass Spectrometry (MS)==<br /> MS ionizes chemical species and sorts them based on their mass-to-charge ratio, offering unparalleled sensitivity for unknown identification.<br /> GC-MS / LC-MS: Couples separation power with mass identification to isolate and name trace contaminants.<br /> ICP-MS (Inductively Coupled Plasma): Detects ultra-trace metals down to parts-per-trillion (ppt) levels.<br /> <br /> Mass Spectrometry coupled with Chromatography (LC-MS or GC-MS) is the most accurate method for identifying and quantifying active ingredients in botanical extracts. Plant extracts are highly complex chemical &quot;matrices&quot; containing hundreds of distinct phytochemicals that must be separated before they can be accurately measured.<br /> ----<br /> We often see test results from UV and HPLC tests which are widely different. This is because stand-alone UV testing (UV-Vis Spectrophotometry) routinely overestimates active ingredients compared to HPLC because UV testing lacks the ability to separate a sample before measuring it.<br /> When a raw botanical extract is placed in a UV spectrophotometer, the machine reads the total light absorbed at a specific wavelength. It cannot distinguish between your target active ingredient and dozens of other identical-looking plant molecules.<br /> The primary reasons for these drastically different results include:<br /> ==1. Total Absorbance vs. Separated Absorbance==<br /> UV-Vis Testing: The sample is placed directly into a glass cuvette. If you are testing for Saffron at 440 nm, the machine counts everything in that liquid that absorbs light at 440 nm. This includes degraded actives, plant pigments, and irrelevant cellular debris.<br /> HPLC Testing: The sample is forced through a chemical column that slows down different molecules at different rates. Your active ingredient is physically separated into its own pure &quot;peak&quot; before it ever hits a detector. HPLC measures only that isolated compound.<br /> ==2. The Overestimation Effect (False Positives)==<br /> Because UV testing tallies up all background chemical &quot;noise,&quot; UV test results are frequently 20% to 200% higher than HPLC results for the exact same batch. Dishonest ingredient suppliers often prefer UV-Vis testing because it artificially inflates the apparent potency of an extract on a Certificate of Analysis (CoA).<br /> ==3. Shared Chromophores==<br /> Molecules absorb ultraviolet light using chemical structures called chromophores (such as alternating double bonds). In a complex botanical extract, many entirely different plant sugars, tannins, or flavonoids share almost identical chromophores. A standalone UV meter sees them all as the exact same substance</div>

Mwood http://gandg.cloud/index.php?title=Testing_Methodologies&diff=958 2026-06-26T13:21:40Z

<p>Mwood: Created page with &quot;All botanical ingredients are analysed in a laboratory, either in-house or by an independent third party, to check that the active ingredients are at the correct levels, per the published specification. There are various methodologies for analytical testing, as far as we are concerned there are three main ones. 1. Spectroscopy (Light &amp; Radiation Interactivity) These methods measure how matter absorbs, emits, or scatters electromagnetic radiation to decode molecular str...&quot;</p> <hr /> <div>All botanical ingredients are analysed in a laboratory, either in-house or by an independent third party, to check that the active ingredients are at the correct levels, per the published specification.<br /> <br /> There are various methodologies for analytical testing, as far as we are concerned there are three main ones.<br /> <br /> 1. Spectroscopy (Light &amp; Radiation Interactivity)<br /> These methods measure how matter absorbs, emits, or scatters electromagnetic radiation to decode molecular structures.<br /> FTIR (Fourier-Transform Infrared): Identifies organic polymers and functional groups by measuring molecular vibrations.<br /> UV-Vis (Ultraviolet-Visible): Quantifies light absorption to find concentrations of coloured compounds in a solution.<br /> NMR (Nuclear Magnetic Resonance): Maps the carbon-hydrogen framework of complex organic molecules.<br /> Raman Spectroscopy: Provides a structural fingerprint through non-destructive laser light scattering.<br /> <br /> 2. Chromatography (Separation Techniques)<br /> Chromatography forces a liquid or gas sample through a stationary phase to separate individual components based on their physical properties.<br /> HPLC (High-Performance Liquid Chemistry): Separates non-volatile liquids, widely used in pharmaceuticals.<br /> GC (Gas Chromatography): Separates volatile gas mixtures, critical for environmental testing.<br /> TLC (Thin-Layer Chromatography): A fast, low-cost screening method used to track chemical reaction progress.<br /> <br /> 3. Mass Spectrometry (MS)<br /> MS ionizes chemical species and sorts them based on their mass-to-charge ratio, offering unparalleled sensitivity for unknown identification.<br /> GC-MS / LC-MS: Couples separation power with mass identification to isolate and name trace contaminants.<br /> ICP-MS (Inductively Coupled Plasma): Detects ultra-trace metals down to parts-per-trillion (ppt) levels.<br /> <br /> Mass Spectrometry coupled with Chromatography (LC-MS or GC-MS) is the most accurate method for identifying and quantifying active ingredients in botanical extracts. Plant extracts are highly complex chemical &quot;matrices&quot; containing hundreds of distinct phytochemicals that must be separated before they can be accurately measured.<br /> <br /> We often see test results from UV and HPLC tests which are widely different. This is because stand-alone UV testing (UV-Vis Spectrophotometry) routinely overestimates active ingredients compared to HPLC because UV testing lacks the ability to separate a sample before measuring it.<br /> When a raw botanical extract is placed in a UV spectrophotometer, the machine reads the total light absorbed at a specific wavelength. It cannot distinguish between your target active ingredient and dozens of other identical-looking plant molecules.<br /> The primary reasons for these drastically different results include:<br /> 1. Total Absorbance vs. Separated Absorbance<br /> UV-Vis Testing: The sample is placed directly into a glass cuvette. If you are testing for Saffron at 440 nm, the machine counts everything in that liquid that absorbs light at 440 nm. This includes degraded actives, plant pigments, and irrelevant cellular debris.<br /> HPLC Testing: The sample is forced through a chemical column that slows down different molecules at different rates. Your active ingredient is physically separated into its own pure &quot;peak&quot; before it ever hits a detector. HPLC measures only that isolated compound.<br /> 2. The Overestimation Effect (False Positives)<br /> Because UV testing tallies up all background chemical &quot;noise,&quot; UV test results are frequently 20% to 200% higher than HPLC results for the exact same batch. Dishonest ingredient suppliers often prefer UV-Vis testing because it artificially inflates the apparent potency of an extract on a Certificate of Analysis (CoA).<br /> 3. Shared Chromophores<br /> Molecules absorb ultraviolet light using chemical structures called chromophores (such as alternating double bonds). In a complex botanical extract, many entirely different plant sugars, tannins, or flavonoids share almost identical chromophores. A standalone UV meter sees them all as the exact same substance</div>

Mwood http://gandg.cloud/index.php?title=Guduchi&diff=957 2026-06-25T14:23:22Z

<p>Mwood: </p> <hr /> <div>Guduchi ''&quot;Tinospora cordifolia&quot;'' (aka gurjo, heart-leaved moonseed, giloy) only has a history of food use as a tea (aqueous infusion) in the EU so any other use would be[[Novel Food | Novel]]. It's only really used in [[Ayurvedic]] and [[Traditional Herbal Remedy (THR) | traditional herbal medicine]].<br /> <br /> Lehvoss are offering a powdered form of a water-extracted product called Tinofend®, which they claim is compliant with UK/EU regulations. We will allow customers to supply it for encapsulation, but they must sign a waiver.<br /> [[Media:Novel_Food_Assessment_of_Tinofend_Combined.pdf]]<br /> <br /> [[Category:Ingredients]]<br /> [[Category:Novel Food]]</div>

Mwood http://gandg.cloud/index.php?title=Guduchi&diff=956 2026-06-25T14:22:06Z

<p>Mwood: </p> <hr /> <div>Guduchi ''&quot;Tinospora cordifolia&quot;'' (aka gurjo, heart-leaved moonseed, giloy) only has a history of food use as a tea (aqueous infusion) in the EU so any other use would be[[Novel Food | Novel]]. It's only really used in [[Ayurvedic]] and [[Traditional Herbal Remedy (THR) | traditional herbal medicine]].<br /> <br /> Lehvoss are offering a powdered form of a water-extracted product called Tinofend®, which they claim is compliant with UK/EU regulations. We will allow customers to supply it for encapsulation, but they must sign a waiver.<br /> [[File:Novel_Food_Assessment_of_Tinofend_Combined.pdf]]<br /> <br /> [[Category:Ingredients]]<br /> [[Category:Novel Food]]</div>

Mwood http://gandg.cloud/index.php?title=File:Novel_Food_Assessment_of_Tinofend_Combined.pdf&diff=955 2026-06-25T14:19:57Z

<p>Mwood: </p> <hr /> <div></div>

Mwood http://gandg.cloud/index.php?title=Guduchi&diff=954 2026-06-25T14:18:20Z

<p>Mwood: </p> <hr /> <div>Guduchi ''&quot;Tinospora cordifolia&quot;'' (aka gurjo, heart-leaved moonseed, giloy) only has a history of food use as a tea (aqueous infusion) in the EU so any other use would be[[Novel Food | Novel]]. It's only really used in [[Ayurvedic]] and [[Traditional Herbal Remedy (THR) | traditional herbal medicine]].<br /> <br /> Lehvoss are offering a powdered form of a water-extracted product called Tinofend®, which they claim is compliant with UK/EU regulations. We will allow customers to supply it for encapsulation, but they must sign a waiver.<br /> <br /> <br /> [[Category:Ingredients]]<br /> [[Category:Novel Food]]</div>

Mwood http://gandg.cloud/index.php?title=Akkermansia_muciniphila&diff=953 2026-06-18T13:11:33Z

<p>Mwood: </p> <hr /> <div>Only pasteurised Akkermansia muciniphila is approved as a Novel Food by EFSA, at levels not exceeding 5 x 10&lt;sup&gt;10&lt;/sup&gt; (which is 50 billion) and maximum doses of 3.4 x 10&lt;sup&gt;10&lt;/sup&gt; (34 billion).<br /> https://eur-lex.europa.eu/legal-content/EN/TXT/HTML/?uri=CELEX:32022R0168<br /> <br /> The company A-Mansia Biotech S.A. have an exclusive until 1/3/2027, so no other versions can be sold until after that date. They only sell their own brand and have not replied to any emails.<br /> https://www.theakkermansiacompany.com/<br /> [[Category:Ingredients]]<br /> [[Category:Novel Food]]</div>

Mwood http://gandg.cloud/index.php?title=Akkermansia_muciniphila&diff=952 2026-06-18T13:10:22Z

<p>Mwood: </p> <hr /> <div>Only pasteurised Akkermansia muciniphila is approved as a Novel Food by EFSA, at levels not exceeding 5 x 10&lt;sup&gt;10&lt;/sup&gt; (which is 50 billion) and maximum doses of 3.4 x 10&lt;sup&gt;10&lt;/sup&gt; (34 billion).<br /> L_2022028EN.01000501.xml<br /> <br /> The company A-Mansia Biotech S.A. have an exclusive until 1/3/2027, so no other versions can be sold until after that date. They only sell their own brand and have not replied to any emails.<br /> The Akkermansia Company | Akkermansia Supplements for The Gut<br /> [[Category:Ingredients]]<br /> [[Category:Novel Food]]</div>

Mwood http://gandg.cloud/index.php?title=Akkermansia_muciniphila&diff=951 2026-06-18T13:09:39Z

<p>Mwood: </p> <hr /> <div>Only pasteurised Akkermansia muciniphila is approved as a Novel Food by EFSA, at levels not exceeding 5 x 10&lt;sup&gt;10&lt;/sup&gt; (which is 50 billion) and maximum doses of 3.4 x 10&lt;sup&gt;10&lt;/sup&gt; (34 billion).<br /> L_2022028EN.01000501.xml<br /> <br /> The company A-Mansia Biotech S.A. have an exclusive until 1/3/2027, so no other versions can be sold until after that date. They only sell their own brand and have not replied to any emails.<br /> The Akkermansia Company | Akkermansia Supplements for The Gut</div>

Mwood http://gandg.cloud/index.php?title=Akkermansia_muciniphila&diff=950 2026-06-18T13:08:39Z

<p>Mwood: Created page with &quot;Only pasteurised Akkermansia muciniphila is approved as a Novel Food by EFSA, at levels not exceeding 5 x 1010 (which is 50 billion) and maximum doses of 3.4 x 1010 (34 billion). L_2022028EN.01000501.xml The company A-Mansia Biotech S.A. have an exclusive until 1/3/2027, so no other versions can be sold until after that date. They only sell their own brand and have not replied to any emails. The Akkermansia Company | Akkermansia Supplements for The Gut&quot;</p> <hr /> <div>Only pasteurised Akkermansia muciniphila is approved as a Novel Food by EFSA, at levels not exceeding 5 x 1010 (which is 50 billion) and maximum doses of 3.4 x 1010 (34 billion).<br /> L_2022028EN.01000501.xml<br /> <br /> The company A-Mansia Biotech S.A. have an exclusive until 1/3/2027, so no other versions can be sold until after that date. They only sell their own brand and have not replied to any emails.<br /> The Akkermansia Company | Akkermansia Supplements for The Gut</div>

Mwood http://gandg.cloud/index.php?title=AMDT&diff=949 2026-06-18T08:17:05Z

<p>Mwood: Created page with &quot;See https://gandg.cloud/index.php/SAMe&quot;</p> <hr /> <div>See https://gandg.cloud/index.php/SAMe</div>

Mwood http://gandg.cloud/index.php?title=SAMe&diff=948 2026-06-18T08:15:53Z

<p>Mwood: </p> <hr /> <div>SAMe ''&quot;S-adenosyl L-methionine&quot;'' is approved in food supplements in Italy, so with EU equivalence it should be usable up to a maximum permitted dose. Could be [[Medicinal ingredients | medicinal]].<br /> <br /> However, S-adenosyl-L-methionine disulfate tosylate (AMDT) is a Novel Food (May 2026).<br /> <br /> <br /> [[Category:Ingredients]]<br /> [[Category:Medicinal]]<br /> [[Category:Novel Food]]</div>

Mwood http://gandg.cloud/index.php?title=Chelated_minerals&diff=947 2026-06-02T07:59:19Z

<p>Mwood: </p> <hr /> <div>At its core, '''mineral chelation''' (pronounced ''key-lay-shun'') is a chemical process that turns a hard-to-absorb mineral into a stealthy, easily digestible package.<br /> <br /> The word &quot;chelation&quot; comes from the Greek word ''chele'', meaning '''&quot;claw.&quot;''' That is the perfect visual for how it works: an organic molecule reaches out and grabs a mineral ion, wrapping around it like a crab claw.<br /> <br /> Here is exactly how the process works, why it’s used, and the science behind it.<br /> <br /> == 1. The Chemistry: Building the &quot;Claw&quot; ==<br /> In their natural, inorganic states (like oxides or carbonates), minerals have a strong electrical charge. This makes them highly reactive, unstable, and difficult for your body to absorb efficiently.<br /> <br /> Chelation chemically bonds that mineral to a '''chelator''' (usually an amino acid like glycine, or an organic acid like citric acid).<br /> <br /> * '''The Mineral (The Guest):''' A positively charged metal ion, such as Zinc (Zn&lt;sup&gt;2+&lt;/sup&gt;), Magnesium (Mg&lt;sup&gt;2+&lt;/sup&gt;), or Iron (Fe&lt;sup&gt;2+&lt;/sup&gt;).<br /> * '''The Chelator (The Host):''' A molecule with at least two atoms (usually nitrogen or oxygen) that can form coordinate covalent bonds with the mineral.<br /> <br /> When they bond, the chelator forms a stable ring structure around the mineral. This effectively '''neutralizes the mineral's electrical charge''' and shields it from reacting with other substances.<br /> <br /> == 2. How it Works in the Body (The &quot;Trojan Horse&quot;) ==<br /> To understand why this matters, let's look at how your body processes a standard mineral versus a chelated mineral during digestion.<br /> <br /> === Standard Minerals (The Vulnerable Way) ===<br /> When you consume a non-chelated mineral (like magnesium oxide), it hits the stomach acid and dissociates into free ions. Because these ions are charged, they start looking for things to bond with. They often bind to '''phytates, oxalates, or dietary fiber''' in your gut, forming insoluble compounds that your body simply excretes. What ''does'' survive has to compete with other minerals for specific ion transporters in the intestinal wall.<br /> <br /> === Chelated Minerals (The Trojan Horse Way) ===<br /> Because a chelated mineral is bound in a neutral ring structure, it safely bypasses the chaotic environment of the stomach without breaking apart.<br /> <br /> # '''No Interference:''' It doesn't bind to phytates or block other minerals.<br /> # '''Stealth Absorption:''' When it reaches the small intestine, the body doesn't recognize it as a mineral. It recognizes it as an ''amino acid''.<br /> # '''The Express Lane:''' Instead of fighting for limited mineral pathways, it utilizes highly efficient amino acid transport pathways to cross the intestinal wall into the bloodstream.<br /> <br /> Once inside the bloodstream, the bond safely breaks, releasing the mineral exactly where the body needs it.<br /> <br /> == 3. A Quick Comparison ==<br /> {| class=&quot;wikitable&quot;<br /> |'''Feature'''<br /> |'''Non-Chelated Mineral (e.g., Magnesium Oxide)'''<br /> |'''Chelated Mineral (e.g., Magnesium Glycinate)'''<br /> |-<br /> |'''Electrical Charge'''<br /> |Highly charged / Reactive<br /> |Neutral / Stable<br /> |-<br /> |'''Bioavailability'''<br /> |Low to Moderate<br /> |High<br /> |-<br /> |'''Stomach Tolerance'''<br /> |Can cause cramping/laxative effects<br /> |Very gentle on the stomach<br /> |-<br /> |'''Cost'''<br /> |Cheap<br /> |More expensive due to processing<br /> |}<br /> <br /> == Real-World Applications ==<br /> <br /> * '''Nutritional Supplements:''' Chelated iron (ferrous bisglycinate) is widely used because standard iron supplements notoriously cause severe nausea and constipation; the chelated version bypasses this.<br /> * '''Agriculture:''' Farmers use chelated micronutrients in fertilizer so that metals like iron don't bind to the soil, ensuring plants can actually drink them up.<br /> * '''Medicine (Chelation Therapy):''' Doctors use heavy-duty synthetic chelators (like EDTA) intravenously to &quot;claw&quot; onto toxic metals (like lead or mercury) in a patient's bloodstream so they can be safely flushed out through urine.<br /> <br /> <br /> == Historical ==<br /> <br /> Before 2010 mineral chelates were just referred to as AACs (e.g. Magnesium AAC), for amino acid chelates. The EU decided it wasn’t specific enough and no one knew which amino acids were actually used, so it came about that Glycine was the main chosen amino acid and when reacted with minerals, formed bisglycinates (e.g. Magnesium bisglycinate). These became the approved forms that are in use today.<br /> [[Category:Ingredients]]</div>

Mwood http://gandg.cloud/index.php?title=SAMe&diff=946 2026-05-29T12:31:53Z

<p>Mwood: </p> <hr /> <div>SAMe ''&quot;S-Adenosyl Methionine&quot;'' is approved in food supplements in Italy, so with EU equivalence it should be usable up to a maximum permitted dose. Could be [[Medicinal ingredients | medicinal]].<br /> <br /> However, S-adenosyl-L-Methionine disulfate tosylate (AMDT) is a Novel Food (May 2026).<br /> <br /> <br /> [[Category:Ingredients]]<br /> [[Category:Medicinal]]<br /> [[Category:Novel Food]]</div>

Mwood http://gandg.cloud/index.php?title=SAMe&diff=945 2026-05-29T12:31:43Z

<p>Mwood: </p> <hr /> <div>SAMe ''&quot;S-Adenosyl Methionine&quot;'' is approved in food supplements in Italy, so with EU equivalence it should be usable up to a maximum permitted dose. Could be [[Medicinal ingredients | medicinal]].<br /> <br /> However, S-adenosyl-L-Methionine disulfate tosylate (AMDT) is a Novel Food (May 2026).<br /> <br /> <br /> [[Category:Ingredients]]<br /> [[Category:Medicinal]]<br /> [[Category:Novel]]<br /> [[Category:Novel Food]]</div>

Mwood http://gandg.cloud/index.php?title=SAMe&diff=944 2026-05-29T12:30:57Z

<p>Mwood: </p> <hr /> <div>SAMe ''&quot;S-Adenosyl Methionine&quot;'' is approved in food supplements in Italy, so with EU equivalence it should be usable up to a maximum permitted dose. Could be [[Medicinal ingredients | medicinal]].<br /> <br /> However, S-adenosyl-L-Methionine disulfate tosylate (AMDT) is a Novel Food (May 2026).<br /> <br /> <br /> [[Category:Ingredients]]<br /> [[Category:Medicinal]]<br /> [[Category:Novel]]</div>

Mwood http://gandg.cloud/index.php?title=Novel_Food&diff=943 2026-05-19T15:07:47Z

<p>Mwood: </p> <hr /> <div>'''What is a Novel Food?'''<br /> <br /> A Novel Food is defined as a food that had not been consumed to a significant degree by humans in the EU before 15 May 1997, when the first Regulation on Novel Food came into force. Novel just means new.<br /> <br /> '''Novel Foods and G&amp;G'''<br /> <br /> G&amp;G (or anyone) is not permitted to use any ingredients that are considered unapproved Novel Foods in supplements that we create. You can find the Novel Food Catalogue from the European Commission [https://webgate.ec.europa.eu/fip/novel_food_catalogue/ here].<br /> <br /> Companies can apply to EFSA (European Food Safety Authority) in the EU or to FSA (Food Standards Agency) in the UK (now we have left the EU) for Novel Food approval. <br /> <br /> The core application procedure involves a systematic, multi-step workflow designed to evaluate safety and risk: <br /> <br /> # Pre-Submission: Before officially applying, businesses should verify whether their product actually requires novel food status. Applicants can use national or EU databases to review existing classifications.<br /> # Dossier Preparation: Applicants must gather extensive scientific and technical evidence. This includes detailed manufacturing processes, compositional analysis, toxicological studies, and nutritional data.<br /> # Submission: The technical dossier is submitted through an online regulated products application portal.<br /> # Safety Assessment: Independent scientific experts and government agencies (such as the FSA in the UK or EFSA in the EU) review the evidence to ensure the food is safe, nutritionally sound, and clearly labeled.<br /> # Authorisation: Once the risk assessment is complete and risk management options are finalized, government ministers or the European Commission make the final decision to authorize the food and add it to the approved market list.<br /> <br /> The full procedure can take up to five years or more to complete. Often the approval is for that specific product from that specific company. As they spent all the time and money on the dossier they usually get exclusivity, sometimes for a specific time period. <br /> <br /> Take a look through the list below that we have compiled ourselves, or search a particular ingredient in the search bar.<br /> <br /> '''Known Novel Foods'''<br /> <br /> [[:Category: Novel Food | List of Novel Foods]]</div>

Mwood http://gandg.cloud/index.php?title=Alpha_GPC&diff=942 2026-05-19T15:00:52Z

<p>Mwood: </p> <hr /> <div>L-alpha-glycerylphosphorylcholine.<br /> <br /> Commonly requested in sport and nootropic products. This is likely medicinal according to the HFMA.<br /> <br /> UPDATE: As of March 2025 an application for authorisation as a Novel food has been lodged with EFSA, when a decision is reached this page will be updated.<br /> <br /> UPDATE: As of May 2026, it has passed the safety assessment by EFSA [https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2026.10008]<br /> <br /> It will now go to the EC for final approval as a Novel Food.<br /> <br /> [[Category:Ingredients]]<br /> [[Category:Medicinal]]</div>

Mwood http://gandg.cloud/index.php?title=Alpha_GPC&diff=941 2026-05-19T15:00:01Z

<p>Mwood: </p> <hr /> <div>L-alpha-glycerylphosphorylcholine.<br /> <br /> Commonly requested in sport and nootropic products. This is likely medicinal according to the HFMA.<br /> <br /> UPDATE: As of March 2025 an application for authorisation as a Novel food has been lodged with EFSA, when a decision is reached this page will be updated.<br /> <br /> UPDATE: As of May 2026, it has passed the safety assessment by EFSA #[https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2026.10008]<br /> <br /> <br /> <br /> [[Category:Ingredients]]<br /> [[Category:Medicinal]]</div>

Mwood http://gandg.cloud/index.php?title=Alpha_GPC&diff=940 2026-05-19T14:59:46Z

<p>Mwood: </p> <hr /> <div>L-alpha-glycerylphosphorylcholine.<br /> <br /> Commonly requested in sport and nootropic products. This is likely medicinal according to the HFMA.<br /> <br /> UPDATE: As of March 2025 an application for authorisation as a Novel food has been lodged with EFSA, when a decision is reached this page will be updated.<br /> <br /> UPDATE: As of May 2026, it has passed the safety assessment by EFSA # [https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2026.10008]<br /> <br /> <br /> <br /> [[Category:Ingredients]]<br /> [[Category:Medicinal]]</div>

Mwood http://gandg.cloud/index.php?title=Alpha_GPC&diff=939 2026-05-19T14:59:04Z

<p>Mwood: </p> <hr /> <div>L-alpha-glycerylphosphorylcholine.<br /> <br /> Commonly requested in sport and nootropic products. This is likely medicinal according to the HFMA.<br /> <br /> UPDATE: As of March 2025 an application for authorisation as a Novel food has been lodged with EFSA, when a decision is reached this page will be updated.<br /> <br /> UPDATE: As of May 2026, it has passed the safety assessment by EFSA [https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2026.10008]<br /> <br /> <br /> <br /> [[Category:Ingredients]]<br /> [[Category:Medicinal]]</div>

Mwood http://gandg.cloud/index.php?title=Alpha_GPC&diff=938 2026-05-19T14:58:22Z

<p>Mwood: </p> <hr /> <div>L-alpha-glycerylphosphorylcholine.<br /> <br /> Commonly requested in sport and nootropic products. This is likely medicinal according to the HFMA.<br /> <br /> UPDATE: As of March 2025 an application for authorisation as a Novel food has been lodged with EFSA, when a decision is reached this page will be updated.<br /> <br /> UPDATE: As of May 2026, it has passed the safety assessment by EFSA [Safety of L‐alpha‐glycerylphosphorylcholine (L‐alpha‐GPC) from soya phospholipids (lecithin) as a novel food pursuant to Regulation (EU) 2015/2283 - - 2026 - EFSA Journal - Wiley Online Library]<br /> <br /> <br /> <br /> [[Category:Ingredients]]<br /> [[Category:Medicinal]]</div>

Mwood http://gandg.cloud/index.php?title=Diamine_Oxidase&diff=937 2026-05-19T13:52:16Z

<p>Mwood: </p> <hr /> <div>Also called DAO, and &quot;amine oxidase, copper-containing, 1&quot;, formerly called histaminase. <br /> <br /> There are currently two versions, one is produced from porcine kidney protein extract, this has Novel Food approval and is a branded product: adiDAO.<br /> <br /> There is also a plant-based version from legume sprouts, this is not yet through the approval line, so it can't be used yet. It is from the same company as above and called: adiDAO Veg.<br /> <br /> Correct as of 19/05/2026.<br /> <br /> [[Category:Ingredients]]<br /> [[Category:Novel Food]]</div>

Mwood http://gandg.cloud/index.php?title=DHEA&diff=936 2026-05-13T14:16:12Z

<p>Mwood: </p> <hr /> <div>DHEA (Dehydroepiandrosterone) also called androstenolone, is a steroid hormone precursor. It is available in the USA as a supplement, but is medicinal here and not approved.<br /> [[Category:Medicinal]]<br /> [[Category:Ingredients]]</div>

Mwood http://gandg.cloud/index.php?title=DHEA&diff=935 2026-05-13T14:15:39Z

<p>Mwood: Created page with &quot;DHEA (Dehydroepiandrosterone) also called androstenolone, is a steroid hormone precursor. It is available in the USA as a supplement, but is medicinal here and not approved.&quot;</p> <hr /> <div>DHEA (Dehydroepiandrosterone) also called androstenolone, is a steroid hormone precursor. It is available in the USA as a supplement, but is medicinal here and not approved.</div>

Mwood http://gandg.cloud/index.php?title=Collagen&diff=934 2026-05-12T13:20:56Z

<p>Mwood: </p> <hr /> <div>There are different types and qualities of collagen. The below document should provide some good, basic education on the subject.<br /> <br /> [[Media:Collagen-101-Guide_05.25.pdf]]<br /> [[Category:Ingredients]]</div>

Mwood http://gandg.cloud/index.php?title=File:Collagen-101-Guide_05.25.pdf&diff=933 2026-05-12T13:19:27Z

<p>Mwood: </p> <hr /> <div></div>

Mwood http://gandg.cloud/index.php?title=Collagen&diff=932 2026-05-12T13:18:22Z

<p>Mwood: Created page with &quot;There are different types and qualities of collagen. The below document should provide some good, basic education on the subject.&quot;</p> <hr /> <div>There are different types and qualities of collagen. The below document should provide some good, basic education on the subject.</div>

Mwood http://gandg.cloud/index.php?title=Fisetin&diff=931 2026-04-17T08:09:37Z

<p>Mwood: </p> <hr /> <div>Fisetin as a pure ingredient or purified extract does not have a history of food use, so is considered a Novel Food. Most extracts are from Smoke Tree (Cotinus coggygria), which would also be Novel, if they are highly purified as above.<br /> It does occur naturally in strawberries but only in microgram amounts.<br /> The bark, leaf and flowers of Smoke Tree are not considered Novel in food supplements.<br /> <br /> <br /> Updated 17/4/2026<br /> <br /> [[Category:Ingredients]]<br /> [[Category:Novel Food]]</div>

Mwood http://gandg.cloud/index.php?title=Cyclic_Dextrin&diff=930 2026-03-24T11:39:54Z

<p>Mwood: </p> <hr /> <div>Cyclic Dextrin or Highly Branched Cyclic Dextrin (HBCD), often branded as Cluster Dextrin®, is a high-performance carbohydrate supplement produced from cornstarch. It is highly water-soluble, breaks down quickly for rapid absorption, and provides sustained energy during intense training. Its low osmotic pressure minimizes stomach discomfort.<br /> <br /> The branded name Cluster Dextrin® is owned by a Japanese company - Glico, their MOQ was 500kgs.<br /> <br /> Generic forms are available with lower prices (although it's not expensive) and MOQs but can only be referred to as Cyclic Dextrin (or HBCD).<br /> [[Category:Ingredients]]</div>

Mwood http://gandg.cloud/index.php?title=Cyclic_Dextrin&diff=929 2026-03-24T11:37:53Z

<p>Mwood: Created page with &quot;Cyclic Dextrin or Highly Branched Cyclic Dextrin (HBCD), often branded as Cluster Dextrin®, is a high-performance carbohydrate supplement produced from cornstarch. It is highly water-soluble, breaks down quickly for rapid absorption, and provides sustained energy during intense training. Its low osmotic pressure minimizes stomach discomfort. The branded name Cluster Dextrin® is owned by a Japanese company - Glico, their MOQ was 500kgs. Generic forms are available wit...&quot;</p> <hr /> <div>Cyclic Dextrin or Highly Branched Cyclic Dextrin (HBCD), often branded as Cluster Dextrin®, is a high-performance carbohydrate supplement produced from cornstarch. It is highly water-soluble, breaks down quickly for rapid absorption, and provides sustained energy during intense training. Its low osmotic pressure minimizes stomach discomfort.<br /> <br /> The branded name Cluster Dextrin® is owned by a Japanese company - Glico, their MOQ was 500kgs.<br /> <br /> Generic forms are available with lower prices (although it's not expensive) and MOQs but can only be referred to as Cyclic Dextrin (or HBCD).</div>

Mwood http://gandg.cloud/index.php?title=Tauroursodeoxycholic_acid_(TUDCA)&diff=928 2026-03-18T16:19:36Z

<p>Mwood: </p> <hr /> <div>Taurourosdeoxycholic acid (aka TUDCA, taurursodiol, ursodoxcoltaurine) is considered [[Medicinal ingredients | Medicinal]] and should not be used by G&amp;G.<br /> In March 2026 it was also listed as Novel by EFSA.<br /> <br /> <br /> [[Category:Ingredients]]<br /> [[Category:Medicinal]]<br /> [[Category:Novel Food]]</div>

Mwood http://gandg.cloud/index.php?title=Tauroursodeoxycholic_acid_(TUDCA)&diff=927 2026-03-18T16:19:01Z

<p>Mwood: </p> <hr /> <div>Taurourosdeoxycholic acid (aka TUDCA, taurursodiol, ursodoxcoltaurine) is considered [[Medicinal ingredients | Medicinal]] and should not be used by G&amp;G.<br /> In March 2026 it was also listed as Novel by EFSA.<br /> <br /> <br /> [[Category:Ingredients]]<br /> [[Category:Medicinal]]</div>

Mwood http://gandg.cloud/index.php?title=Tauroursodeoxycholic_acid_(TUDCA)&diff=926 2026-03-18T16:18:43Z

<p>Mwood: </p> <hr /> <div>Taurourosdeoxycholic acid (aka TUDCA, taurursodiol, ursodoxcoltaurine) is considered [[Medicinal ingredients | Medicinal]] and should not be used by G&amp;G.<br /> In March 2026 it was also listed as Novel by EFSA.<br /> <br /> <br /> [[Category:Ingredients]]<br /> [[Category:Medicinal]]<br /> [[Category:Novel]]</div>

Mwood http://gandg.cloud/index.php?title=Glucosamine&diff=925 2026-03-17T10:21:58Z

<p>Mwood: </p> <hr /> <div>In 2018 the MHRA reviewed Glucosamine use and set a limit for food supplements.<br /> <br /> Anything at or above 1178mg of Glucosamine (base) is deemed a pharmacological dose, food supplements would therefore have to be lower.<br /> <br /> To ensure this clear space can be demonstrated, discussions between HFMA, CRN UK, and PAGB have led to an upper level, for guidance purposes only as follows:<br /> <br /> * 1100mg Glucosamine (base) …which is equivalent to:<br /> * 1400mg Glucosamine Sulphate,<br /> * 1350mg N-Acetylglucosamine (NAG),<br /> * 1325mg Glucosamine HCl, or<br /> * 1858mg Glucosamine Sulphate 2KCl<br /> <br /> [[Category:Ingredients]]</div>

Mwood http://gandg.cloud/index.php?title=Elemental_Weights_of_Minerals&diff=924 2026-02-13T13:37:27Z

<p>Mwood: </p> <hr /> <div>Minerals are provided, in dietary supplements, as salts or compounds that are approved forms for food use. Each compound will contain a different amount of the specific mineral, this is called the elemental weight (as minerals are elements).<br /> <br /> The elemental weights are usually shown in Access as the purity figure, this allows you to calculate how much of a mineral goes in a capsule.<br /> <br /> Sometimes you might get asked if there is another product with a higher amount of a specific mineral. A chart has been created and is linked below, which shows all the elemental weights of all the available forms.<br /> <br /> <br /> [[Media:Mineral_salts_elemental_weights.pdf]]</div>

Mwood http://gandg.cloud/index.php?title=File:Mineral_salts_elemental_weights.pdf&diff=923 2026-02-13T13:36:53Z

<p>Mwood: </p> <hr /> <div></div>

Mwood http://gandg.cloud/index.php?title=Benfotiamine&diff=921 2026-01-05T10:50:59Z

<p>Mwood: </p> <hr /> <div>Benfotiamine is a synthetic (lab-made) derivative of Thiamine (Vitamin B1). It is fat-soluble, unlike Thiamine HCl, which is water-soluble.<br /> It is not approved in the UK or EU as a form of B1, in 2008 an EFSA safety assessment was done and there was insufficient evidence to approve it.<br /> <br /> It was added to the Novel Food Catalogue in December 2025 as an unapproved Novel Food.<br /> <br /> It is legal in the USA and is a drug/medicine in some other countries.<br /> [[Category:Ingredients]]<br /> [[Category:Novel Food]]</div>

Mwood http://gandg.cloud/index.php?title=Clear_Whey&diff=920 2025-12-18T14:30:25Z

<p>Mwood: </p> <hr /> <div>Data on Clear Whey:<br /> <br /> Regular whey comes from whey concentrate, the least processed type which contains small amounts of lactose and fat, and clocks in at about 70-80% protein. Clear whey comes from whey isolate, which goes through a greater refining process, with lower levels of lactose and around 90% protein content.<br /> <br /> Clear Whey has several disadvantages:<br /> <br /> The high acidity can be detrimental to the stomach and blood pH balance. The cost is increased by additional production stages and the marketing hype surrounding this product. Expect to pay around €20 more per kg than classic whey.<br /> <br /> The &quot;fruity&quot; taste must be reinforced by the use of synthetic compounds to mask the undesirable taste, in particular sweeteners, synthetic flavours, acidity correctors, acidifiers... All ingredients with no nutritional value and potentially harmful to long-term health.<br /> <br /> Despite its many advertised selling points, Clear Whey is an ultra-processed product with no nutritional superiority, and sold at a much higher price.<br /> [[Category:Ingredients]]</div>

Mwood http://gandg.cloud/index.php?title=Clear_Whey&diff=919 2025-12-18T14:28:30Z

<p>Mwood: Created page with &quot;Data on Clear Whey: Regular whey comes from whey concentrate, the least processed type which contains small amounts of lactose and fat, and clocks in at about 70-80% protein. Clear whey comes from whey isolate, which goes through a greater refining process, with lower levels of lactose and around 90% protein content. Clear Whey has several disadvantages: The high acidity can be detrimental to the stomach and blood pH balance. The cost is increased by additional produc...&quot;</p> <hr /> <div>Data on Clear Whey:<br /> <br /> Regular whey comes from whey concentrate, the least processed type which contains small amounts of lactose and fat, and clocks in at about 70-80% protein. Clear whey comes from whey isolate, which goes through a greater refining process, with lower levels of lactose and around 90% protein content.<br /> <br /> Clear Whey has several disadvantages:<br /> <br /> The high acidity can be detrimental to the stomach and blood pH balance. The cost is increased by additional production stages and the marketing hype surrounding this product. Expect to pay around €20 more per kg than classic whey.<br /> <br /> The fruity taste must be reinforced by the use of synthetic compounds to mask undesirable tastes, in particular sweeteners, synthetic flavours, acidity correctors, acidifiers... All ingredients with no nutritional value and potentially harmful to long-term health.<br /> <br /> Despite its many advertised selling points, Clear Whey is an ultra-processed product with no nutritional superiority, and sold at a much higher price.</div>

Mwood http://gandg.cloud/index.php?title=Neem&diff=918 2025-12-09T11:27:40Z

<p>Mwood: </p> <hr /> <div>Neem (Azadirachta indica ) also known as Indian Lilac, Crack Jack, Paradise Tree, has been evaluated by EFSA and info updated 24/11/25. The fruits are not Novel in food supplements, the leaves and oil are Novel in foods and food supplements. As this post-dates Brexit an FSA decision would be needed to establish the UK position.<br /> [[Category:Ingredients]]<br /> [[Category:Novel Food]]</div>

Mwood http://gandg.cloud/index.php?title=Neem&diff=917 2025-12-09T11:27:06Z

<p>Mwood: Created page with &quot;Neem (Azadirachta indica ) also known as Indian Lilac, Crack Jack, Paradise Tree, has been evaluated by EFSA and info updated 24/11/25. The fruits are not Novel in food supplements, the leaves and oil are Novel in foods and food supplements. As this post-dates Brexit an FSA decision would be needed to establish the UK position.&quot;</p> <hr /> <div>Neem (Azadirachta indica ) also known as Indian Lilac, Crack Jack, Paradise Tree, has been evaluated by EFSA and info updated 24/11/25. The fruits are not Novel in food supplements, the leaves and oil are Novel in foods and food supplements. As this post-dates Brexit an FSA decision would be needed to establish the UK position.</div>

Mwood